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Phase I, dose de-escalation to minimal effective pharmacologic dose trial of sodium phenylbutyrate (PB, NSC 657802) in combination with 5-azacytidine (5-AZA, NSC 102816) in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)

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Trial Profile

Phase I, dose de-escalation to minimal effective pharmacologic dose trial of sodium phenylbutyrate (PB, NSC 657802) in combination with 5-azacytidine (5-AZA, NSC 102816) in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Azacitidine (Primary) ; Sodium phenylbutyrate (Primary)
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions

    • Most Recent Events

    • 11 Jan 2007 Status changed from in progress to completed
    • 11 Oct 2005 New trial record.

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