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A Multicenter, Randomized, Double-Blind, Comparative Trial Of A Novel CCR5 Antagonist, UK-427,857, In Combination With Zidovudine/Lamivudine Versus Efavirenz In Combination With Zidovudine/Lamivudine For The Treatment Of Antiretroviral-Naive HIV-1 Infected Subjects

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Trial Profile

A Multicenter, Randomized, Double-Blind, Comparative Trial Of A Novel CCR5 Antagonist, UK-427,857, In Combination With Zidovudine/Lamivudine Versus Efavirenz In Combination With Zidovudine/Lamivudine For The Treatment Of Antiretroviral-Naive HIV-1 Infected Subjects

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 08 Oct 2021

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At a glance

  • Drugs Maraviroc (Primary) ; Efavirenz; Lamivudine/zidovudine
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms MERIT; MERIT-ES
  • Sponsors ViiV Healthcare
  • Most Recent Events

    • 07 Sep 2018 Results published in the Journal of Clinical Pharmacology
    • 27 Oct 2017 Results of post-hoc analysis (n=895) assessing the effect of maraviroc versus efavirenz on the CD4/CD8 ratio dynamics, presented at the 16th European AIDS Conference.
    • 09 Oct 2017 Results (n=721) of post-hoc analysis of Merit study (NCT00098293, NCT03178084), published in the Antimicrobial Agents and Chemotherapy Journal.
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