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A multicenter, double-blind, randomized, placebo-controlled study to evaluate the effects of ezetimibe + simvastatin on clinical outcomes in patients with aortic stenosis

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Trial Profile

A multicenter, double-blind, randomized, placebo-controlled study to evaluate the effects of ezetimibe + simvastatin on clinical outcomes in patients with aortic stenosis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 05 May 2022

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At a glance

  • Drugs Ezetimibe/simvastatin (Primary)
  • Indications Aortic valve stenosis; Cardiovascular disorders; Myocardial infarction; Stroke
  • Focus Registrational; Therapeutic Use
  • Acronyms SEAS
  • Sponsors Merck Sharp & Dohme Corp.; Organon

    • Most Recent Events

    • 19 Nov 2020 Results (n=1667) of sub-study in participants who had sodium ascertained at baseline from this trial published in the American Journal of Cardiology
    • 01 Sep 2020 Results of post hoc analysis examining the association between the hsTnT levels and AS severity in asymptomatic AS patients presented at the ESC Congress 2020 - Annual Congress of the European Society of Cardiology
    • 31 Jul 2020 Results of Retrospective analysis of the of this study assessing the incidence and potential risk factors of SCD in this prospectively followed, low-risk cohort of asymptomatic patients with AS, published in the Heart.

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