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A Phase III, Randomized, Open-Label Comparison of Lopinavir/Ritonavir Plus Efavirenz Versus Lopinavir/Ritonavir Plus 2 NRTIs Versus Efavirenz Plus 2 NRTIs as Initial Therapy for HIV-1 Infection.

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A Phase III, Randomized, Open-Label Comparison of Lopinavir/Ritonavir Plus Efavirenz Versus Lopinavir/Ritonavir Plus 2 NRTIs Versus Efavirenz Plus 2 NRTIs as Initial Therapy for HIV-1 Infection.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 02 Nov 2021

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At a glance

  • Drugs Efavirenz (Primary) ; Lamivudine (Primary) ; Lopinavir/ritonavir (Primary) ; Nucleoside reverse transcriptase inhibitors (Primary) ; Stavudine (Primary) ; Tenofovir disoproxil fumarate (Primary) ; Zidovudine (Primary)
  • Indications HIV-1 infections
  • Focus Therapeutic Use

    • Most Recent Events

    • 23 Aug 2020 Results (n=757) of a retrospective, observational cohort of individuals receiving primary care at the vanderbilt comprehensive care clinic and a retrospective analysis of a clinical trials (A5095, A5142 and A5202 and did not receive INSTIs) cohort from efavirenz containing arms of ACTG protocols has been published in the Clinical Infectious Diseases.
    • 01 Sep 2017 Results assessing the association between efavirenz metabolizer genotype and suicidality using pooled data from four clinical trials (A5095, A5142 ,A5175, A5202), published in the Journal of Infectious Diseases.
    • 16 Feb 2017 Results of pooled analysis of 3 ACTG U.S based randomized trials (A5142, A5202 and A5257) presented at the 24th Conference on Retroviruses and Opportunistic Infections

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