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A multicenter, randomized, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427, 857 [maraviroc], in combination with optimized background therapy versus optimized background therapy alone for the treatment of antiretroviral-experienced HIV-1 infected subjects.

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A multicenter, randomized, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427, 857 [maraviroc], in combination with optimized background therapy versus optimized background therapy alone for the treatment of antiretroviral-experienced HIV-1 infected subjects.

Status: Completed
Phase of Trial: Phase II/III

Latest Information Update: 25 Oct 2021

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At a glance

  • Drugs Maraviroc (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms MOTIVATE-1
  • Sponsors ViiV Healthcare

    • Most Recent Events

    • 07 Oct 2021 Results assessing the lack of cross-resistance between the prodrug of temsavir (TMR) and ibalizumab or maraviroc from clinical samples from the BRIGHTE and MOTIVATE Phase 3 studies, published in the AIDS.
    • 10 Mar 2021 Results of six envelopes derived from plasma samples from participants in the BRIGHTE study and 5 R5-tropic MVC-resistant envelopes from the MOTIVATE trials, assessing susceptibility to temsavir is not linked to Iba or Mvc resistance, presented at the 28th Conference on Retroviruses and Opportunistic Infections.
    • 12 Sep 2015 Pooled analysis (SINGLE + MOTIVATE); Missing CD4+ cell response, results published in the HIV Clinical Trials.

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