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A randomized phase III study to compare conventional chemotherapy (CHOEP-14) + rituximab vs high-dose chemotherapy followed by autologous stem cell transplantation (Mega-CHOEP-21) + rituximab in younger patients with aggressive NHL

Trial Profile

A randomized phase III study to compare conventional chemotherapy (CHOEP-14) + rituximab vs high-dose chemotherapy followed by autologous stem cell transplantation (Mega-CHOEP-21) + rituximab in younger patients with aggressive NHL

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 29 May 2023

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At a glance

  • Drugs Rituximab (Primary) ; Cyclophosphamide; Doxorubicin; Etoposide; Prednisone; Vincristine
  • Indications B-cell lymphoma
  • Focus Therapeutic Use
  • Acronyms R-MegaCHOEP
  • Most Recent Events

    • 13 Mar 2020 Results comparing International prognostic indices in diffuse large B-cell lymphoma using different trials published in the Blood
    • 06 Nov 2019 Results of 10-year follow-up of this study, were released in the 61st Annual Meeting and Exposition of the American Society of Hematology.
    • 01 Aug 2017 Results of pooled data of clinical impact of the cell-of-origin classification and the MYC/ BCL2 dual expresser status in diffuse large B-cell lymphoma treated within two prospective clinical trials (RICOVER-60 and R-MegaCHOEP) of the German high-grade non-Hodgkin's lymphoma study group were, published in the Journal of Clinical Oncology.
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