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A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Risk Subjects Presenting With Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial - IMPROVE IT)

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A Multicenter, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (Ezetimibe/Simvastatin Tablet) vs Simvastatin Monotherapy in High-Risk Subjects Presenting With Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial - IMPROVE IT)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 05 May 2022

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At a glance

  • Drugs Ezetimibe/simvastatin (Primary) ; Simvastatin
  • Indications Acute coronary syndromes; Cardiovascular disorders; Stroke; Unstable angina pectoris
  • Focus Registrational; Therapeutic Use
  • Acronyms IMPROVE-IT
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.; Schering-Plough

    • Most Recent Events

    • 12 Oct 2021 Results assessing the relationship between baseline LDL-C above and below 70 mg/dL and the benefit of adding ezetimibe to statin in patients post-acute coronary syndrome (ACS), published in the Journal of the American College of Cardiology.
    • 27 Aug 2019 Results assessing the role of established CV biomarkers in assessing likely benefit with Ezetimibe added to statin therapy in post-ACS patients in the biomarker substudy, published in the Journal of the American College of Cardiology
    • 25 Jan 2019 Results published in the American Journal of Cardiology

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