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The Insulin Resistance Intervention after Stroke Trial A randomized, placebo-controlled trial of pioglitazone, compared with placebo, for prevention of stroke and myocardial infarction after ischemic stroke and transient ischemic attack

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Trial Profile

The Insulin Resistance Intervention after Stroke Trial A randomized, placebo-controlled trial of pioglitazone, compared with placebo, for prevention of stroke and myocardial infarction after ischemic stroke and transient ischemic attack

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Dec 2022

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At a glance

  • Drugs Pioglitazone (Primary)
  • Indications Myocardial infarction; Stroke
  • Focus Therapeutic Use
  • Acronyms IRIS

    • Most Recent Events

    • 07 Nov 2022 Results evaluating whether machine learning strategy of predictive enrichment can reduce the size of RCTs through adaptive enrollment based on projected response profiles; by performing post-hoc analysis of individual patient data from IRIS trial, presented at the American Heart Association Scientific Sessions 2022
    • 26 Apr 2022 Results examining the added benefit of outcome event adjudication presented, at the 74th Annual Meeting of the American Academy of Neurology 2022
    • 07 Feb 2019 Post hoc analysis results (n=2885) were published in the JAMA Neurology.

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