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An ascending single and multiple dose study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of HKI-272 [neratinib] administered orally to subjects with HER-2/NEU or HER-1/EGFR [epidermal growth factor receptor]-positive tumors

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Trial Profile

An ascending single and multiple dose study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of HKI-272 [neratinib] administered orally to subjects with HER-2/NEU or HER-1/EGFR [epidermal growth factor receptor]-positive tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Neratinib (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions
  • Sponsors Puma Biotechnology

    • Most Recent Events

    • 11 May 2012 Additional company (Puma Biotechnology) added in association as reported by ClinicalTrials.gov.
    • 04 Dec 2007 Status changed from in progress to completed as reported on clinicaltrials.gov website.
    • 07 Nov 2005 New trial record.

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