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Evaluation of Quantitative and Qualitative Antibody Responses to Streptococcus Pneumoniae and Haemophilus Influenzae Type b Conjugate Vaccines Amongst HIV-1-Exposed-Infected Children That Are Receiving Vs. Those Not Receiving Antiretroviral Therapy, as Well as Among HIV-1-Exposed-Uninfected Children and HIV-1-Unexposed-Uninfected Children

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Trial Profile

Evaluation of Quantitative and Qualitative Antibody Responses to Streptococcus Pneumoniae and Haemophilus Influenzae Type b Conjugate Vaccines Amongst HIV-1-Exposed-Infected Children That Are Receiving Vs. Those Not Receiving Antiretroviral Therapy, as Well as Among HIV-1-Exposed-Uninfected Children and HIV-1-Unexposed-Uninfected Children

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 21 Jul 2022

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At a glance

  • Drugs Pneumococcal 7-valent CRM197 vaccine conjugate (Primary)
  • Indications Haemophilus infections; HIV-1 infections; Pneumococcal infections
  • Focus Pharmacodynamics
  • Acronyms CIPRA Project-4; CIPRA-SA Project-4; CIPRA-SA-4; CIPRA-ZA Project-4; CIPRA-ZA-4

    • Most Recent Events

    • 15 Feb 2020 Results (n=579) assessing effect of HIV-exposure and timing of antiretroviral treatment initiation in children living with HIV on antibody persistence and memory responses to Haemophilus influenzae type b and pneumococcal polysaccharide-protein conjugate vaccines from two clinical trials: NCT00099658 and NCT00102960 were published in the Vaccine
    • 23 Dec 2010 Planned end date changed from 1 May 2010 to 1 Jun 2014 as reported by ClinicalTrials.gov.
    • 22 Jul 2009 Interim results reported at the 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention.

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