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A prospective, multinational, multicenter trial to compare the effects of amlodipine/benazepril to benazepril and hydrochlorothiazide combined on the reduction of cardiovascular morbidity and mortality in patients with high risk hypertension

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Trial Profile

A prospective, multinational, multicenter trial to compare the effects of amlodipine/benazepril to benazepril and hydrochlorothiazide combined on the reduction of cardiovascular morbidity and mortality in patients with high risk hypertension

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 26 Oct 2023

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At a glance

  • Drugs Amlodipine/benazepril (Primary) ; Benazepril/hydrochlorothiazide
  • Indications Cardiovascular disorders; Hypertension
  • Focus Therapeutic Use
  • Acronyms ACCOMPLISH
  • Sponsors Novartis

    • Most Recent Events

    • 20 Nov 2020 Results of post hoc analysis (n=5221) comparing the primary composite outcome between the 2 combination-treatment limbs in patients achieving a desired systolic blood pressure and those with apparent resistant hypertension, published in the American Journal of Hypertension
    • 30 Aug 2010 A late-breaking analysis reviewing 21 trials, including ACCOMPLISH, was presented at the European Society of Cardiology (ESC) Congress, according to a European Society of Cardiology media release.
    • 01 Jul 2010 Results of a sub-study on effects on 24-hour ambulatory blood pressure were presented in the New England Journal of Medicine, available from http://dx.doi.org/10.1056/nejmc1001410.

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