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A three arm, prospective study to compare the effect of six weeks exposure to the combination of lopinavir (LPVr)/Combivir (AZT [zidovudine]/3TC [lamivudine]) versus lopinavir alone or Combivir alone in HIV-negative healthy subjects on the development of abnormalities of lipid and glucose metabolism

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A three arm, prospective study to compare the effect of six weeks exposure to the combination of lopinavir (LPVr)/Combivir (AZT [zidovudine]/3TC [lamivudine]) versus lopinavir alone or Combivir alone in HIV-negative healthy subjects on the development of abnormalities of lipid and glucose metabolism

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 30 Sep 2022

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At a glance

  • Drugs Lamivudine/zidovudine (Primary) ; Lopinavir/ritonavir (Primary) ; Lopinavir
  • Indications HIV infections
  • Focus Adverse reactions; Biomarker; Pharmacodynamics
  • Acronyms SAMA002

    • Most Recent Events

    • 06 Mar 2013 Pooled analysis of bone turnover markers presented at the 20th Conference on Retroviruses and Opportunistic Infections.
    • 11 Apr 2012 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 29 Aug 2011 New source identified and integrated (Australian New Zealand Clinical Trials Registry; ACTRN12605000661673).

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