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A Double-Blind, Controlled, Randomized, Phase III Study of the Efficacy of an HPV16/18 VLP Vaccine in the Prevention of Advanced Cervical Intraepithelial Neoplasia (CIN2, CIN3, Adenocarcinoma In Situ [AIS] and Invasive Cervical Cancer) Associated With HPV 16 or HPV 18 Cervical Infection in Healthy Young Adult Women in Costa Rica

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Trial Profile

A Double-Blind, Controlled, Randomized, Phase III Study of the Efficacy of an HPV16/18 VLP Vaccine in the Prevention of Advanced Cervical Intraepithelial Neoplasia (CIN2, CIN3, Adenocarcinoma In Situ [AIS] and Invasive Cervical Cancer) Associated With HPV 16 or HPV 18 Cervical Infection in Healthy Young Adult Women in Costa Rica

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 Apr 2023

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At a glance

  • Drugs Human papillomavirus vaccine recombinant bivalent Japan Vaccine/MedImmune (Primary) ; Alum; AS04A; Hepatitis A vaccine inactivated
  • Indications Adenocarcinoma; Anal cancer; Cervical cancer; Cervical intraepithelial neoplasia; Human papillomavirus infections
  • Focus Therapeutic Use
  • Acronyms CVT
  • Sponsors GlaxoSmithKline; GSK

    • Most Recent Events

    • 11 Apr 2023 Results(n=3727) assessing human papillomavirus vaccine efficacy from a single-arm trial published in the Journal of the National Cancer Institute
    • 01 Dec 2020 Results published in the Lancet Oncology.
    • 05 Sep 2020 Results of pooled analysis of data from 2 trials (NCT00128661 and NCT00122681) published in the Journal of Infectious Diseases

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