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A randomized, double-blind, stratified, placebo-controlled, parallel-group study of the efficacy and safety of the ACAT inhibitor CD-505 [pactimibe] for reducing the progression of atherosclerosis in subjects with heterozygous familial hypercholesterolemia and carotid atherosclerosis using carotid ultrasound (CUS).

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Trial Profile

A randomized, double-blind, stratified, placebo-controlled, parallel-group study of the efficacy and safety of the ACAT inhibitor CD-505 [pactimibe] for reducing the progression of atherosclerosis in subjects with heterozygous familial hypercholesterolemia and carotid atherosclerosis using carotid ultrasound (CUS).

Status: Discontinued
Phase of Trial: Phase II/III

Latest Information Update: 19 Feb 2024

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At a glance

  • Drugs Pactimibe (Primary)
  • Indications Atherosclerosis; Hyperlipoproteinaemia type II
  • Focus Registrational; Therapeutic Use
  • Acronyms CAPTIVATE
  • Sponsors Daiichi Sankyo Inc
  • Most Recent Events

    • 17 Jan 2012 Planned End Date (Mar 2006) added as reported by ClinicalTrials.gov.
    • 18 Mar 2009 Results published in JAMA: the Journal of the American Medical Association 301: 1131-1139, No. 11, 18 Mar 2009.
    • 07 Aug 2006 Status change

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