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Treatment of Newly Diagnosed Childhood Acute Myeloid Leukemia (AML) Using Intensive MRC-Based Therapy and Gemtuzumab Ozogamicin (GMTZ): A COG Pilot Study

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Trial Profile

Treatment of Newly Diagnosed Childhood Acute Myeloid Leukemia (AML) Using Intensive MRC-Based Therapy and Gemtuzumab Ozogamicin (GMTZ): A COG Pilot Study

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 15 Jan 2024

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At a glance

  • Drugs Gemtuzumab ozogamicin (Primary) ; Asparaginase; Busulfan; Ciclosporin; Ciclosporin; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Methotrexate; Mitoxantrone
  • Indications Acute myeloid leukaemia; Graft-versus-host disease
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 10 Jan 2024 Results from COG-AAML03P1 and COG-AAAML0531, analyzing genetic variation in DNA damage response pathway and response to Gemtuzumab Ozogamicin in pediatric AML, published in the Clinical Cancer Research
    • 01 Aug 2022 LASSO regression modeling was used to develop a 10-gene DNA damage response gene expression score (CalDDR-GEx10) predictive of clinical outcome in pediatric AML patients treated with treatment regimen containing GO from the AAML03P1 and AAML0531 trials, published in the Leukemia.
    • 18 Mar 2022 Genomic data of patients from two studies (AAML03P1 and AAAML0531 trials) were used to assess the pharmacogenomic impact of SNPs in DNA damage response (DDR) pathway genes on response to GO treatment, presented at the 123rd Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics.
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