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A Random-Assignment Study of Hepatic Arterial Infusion of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) (Delcath System) Versus Best Alternative Care for Ocular and Cutaneous Melanoma Metastatic to the Liver

Trial Profile

A Random-Assignment Study of Hepatic Arterial Infusion of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) (Delcath System) Versus Best Alternative Care for Ocular and Cutaneous Melanoma Metastatic to the Liver

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 15 Apr 2026

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At a glance

  • Drugs Melphalan (Primary) ; Antineoplastics
  • Indications Liver metastases
  • Focus Registrational; Therapeutic Use
  • Sponsors Delcath Systems

Most Recent Events

  • 06 Apr 2026 According to Delcath systems media release, company announced that its proprietary CHEMOSAT Hepatic Delivery System for Melphalan percutaneous hepatic perfusion (M-PHP) has been included as a recommended liver-directed regional therapy option in the newly published Uveal Melanoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up (April 2026).
  • 29 Mar 2018 According to a Delcath systems media release, results from this were presented at the 2018 Society of Surgical Oncology Annual Cancer Symposium (SSO)
  • 09 Dec 2015 According to a Delcath media release, results from this trial were published in Annals of Surgical Oncology.

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