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A randomised clinical trial of treatment for fluorouracil-resistant advanced colorectal cancer comparing standard single-agent irinotecan versus irinotecan plus panitumumab and versus irinotecan plus ciclosporin

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Trial Profile

A randomised clinical trial of treatment for fluorouracil-resistant advanced colorectal cancer comparing standard single-agent irinotecan versus irinotecan plus panitumumab and versus irinotecan plus ciclosporin

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 03 Jun 2022

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At a glance

  • Drugs Ciclosporin (Primary) ; Irinotecan (Primary) ; Panitumumab (Primary)
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms PICCOLO

Most Recent Events

  • 12 Jul 2021 Results assessing effect of anti-EGFR therapy on survival in different consensus molecular subtypes (CMSs) and stratified by primary tumour location retrospectively in two studies (COIN & PICCOLO), published in the British Journal of Cancer.
  • 22 Apr 2021 Results (n=274) evaluating Artificial intelligence-assisted amphiregulin and epiregulin immunohistochemistry predicts panitumumab benefit in RAS wild-type metastatic colorectal cancer published in the Clinical Cancer Research
  • 17 Jan 2021 Results of retrospective biomarker study within the PICCOLO trial, evaluating AI assisted immunohistochemical tumor amphiregulin and epiregulin expression, presented at the 2021 Gastrointestinal Cancers Symposium

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