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DIRECT: DIabetic Retinopathy Candesartan Trials. Effects of candesartan cilexetil (candesartan) on diabetic retinopathy in type 1 diabetic patients with retinopathy

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Trial Profile

DIRECT: DIabetic Retinopathy Candesartan Trials. Effects of candesartan cilexetil (candesartan) on diabetic retinopathy in type 1 diabetic patients with retinopathy

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 03 Dec 2021

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At a glance

  • Drugs Candesartan cilexetil (Primary)
  • Indications Diabetic nephropathies; Diabetic retinopathy; Proteinuria
  • Focus Registrational; Therapeutic Use
  • Acronyms DIRECT; DIRECT-Protect-1
  • Sponsors AstraZeneca
  • Most Recent Events

    • 06 Jul 2021 Results (N=1575) post hoc analysis from two randomized controlled trials, DIRECT-Protect 1 and 2 assessing candesartan on progression of diabetic retinopathy in type 1 and type 2 diabetes published in the Diabetic Medicine
    • 29 Jun 2021 Results of post-hoc analysis assessing the effect of candesartan on the progression of diabetic retinopathy in 783 and 792 randomly chosen subjects from two randomized controlled trials (DIRECT-Protect 1 and DIRECT-Protect 2), presented at the 81st Annual Scientific Sessions of the American Diabetes Association.
    • 07 Jul 2009 Results of a prespecified pooled analysis of the three DIRECT trials (DIRECT-Renal) published in Annals of Internal Medicine.

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