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A phase 3, randomized, open-label study evaluating DN-101 in combination with docetaxel in androgen-independent prostate cancer (AIPC) (ASCENT-2)

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Trial Profile

A phase 3, randomized, open-label study evaluating DN-101 in combination with docetaxel in androgen-independent prostate cancer (AIPC) (ASCENT-2)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 01 Jul 2022

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At a glance

  • Drugs Calcitriol (Primary) ; Docetaxel (Primary) ; Dexamethasone; Prednisone
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms ASCENT-2
  • Sponsors Transcept Pharmaceuticals Inc
  • Most Recent Events

    • 07 Jun 2022 Results (n=2028) from 4 randomized phase 3 trials (NCT00273338, NCT00988208, NCT00617669, and NCT00519285) presented at the 58th Annual Meeting of the American Society of Clinical Oncology
    • 18 May 2020 Results (n=1577) of Ascent2, Mainsail and Venice trials, inverse correlation between obesity and mortality in patients, presented at the 115th Annual Meeting of the American Urological Association
    • 18 May 2020 Results predicting toxicity related Docetaxel discontinuation using phase III trials presented at the 115th Annual Meeting of the American Urological Association
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