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A Phase I Study of the Safety and Pharmacokinetics of Escalating Intravenous Doses of the Proteasome Inhibitor PR-171 in Patients With Hematological Malignancies.

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Trial Profile

A Phase I Study of the Safety and Pharmacokinetics of Escalating Intravenous Doses of the Proteasome Inhibitor PR-171 in Patients With Hematological Malignancies.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Carfilzomib (Primary) ; Dexamethasone
  • Indications Haematological malignancies; Hodgkin's disease; Multiple myeloma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Onyx Pharmaceuticals
  • Most Recent Events

    • 02 Dec 2015 Trial focus has been changed from AR to PK + AR and end points related to pharmacokinetics are added. Number of treatment arms changed from 1 to 11 and treatments related to different dosages are added as reported by ClinicalTrials.gov record.
    • 30 Aug 2011 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 30 Aug 2011 Actual end date (Sep 2010) added as reported by ClinicalTrials.gov.
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