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A multicenter, randomized, double-blind, placebo-controlled trial of golimumab, a fully human anti-TNFa [tumour necrosis factor alpha] monoclonal antibody, administered subcutaneously in subjects with active rheumatoid arthritis and previously treated with biologic anti- TNFa agent(s).

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Trial Profile

A multicenter, randomized, double-blind, placebo-controlled trial of golimumab, a fully human anti-TNFa [tumour necrosis factor alpha] monoclonal antibody, administered subcutaneously in subjects with active rheumatoid arthritis and previously treated with biologic anti- TNFa agent(s).

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 01 Dec 2023

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At a glance

  • Drugs Golimumab (Primary)
  • Indications Rheumatoid arthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms GO-AFTER
  • Sponsors Centocor

    • Most Recent Events

    • 01 Dec 2023 Results of post hoc pooled analysis from GO-BEFORE, GO-AFTER, and GO-FORWARD, GO-REVEAL and GO-RAISE assessing Long-term golimumab persistence, published in the Clinical Rheumatology
    • 04 Jun 2022 Results assessing probability of GLM treatment retention over a 5-year period in adult patients with immune-mediated rheumatic diseases, by indication and line of therapy, using pooled data from five Phase III trials (GO-BEFORE, GO-AFTER and GO-FORWARD 3,8 ), PsA (GO-REVEAL), and AS (GO-RAISE)) presented at the 23rd Annual Congress of the European League Against Rheumatism.
    • 05 Jun 2021 Results (n=398) a post hoc analysis of GO-AFTER and the SIRROUND-T trials investigating golimumab and sirukumab, respectively, compared with PLC in patients who had an insufficient response to biological DMARDs presented at the 22nd Annual Congress of the European League Against Rheumatism

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