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Efficacy and Safety of Memantine Hydrochloride, a low affinity antagonist to N-Methyl-D-Aspartate (NMDA) type receptors, in the prevention of cognitive decline and disease progression in older people with Down's syndrome, with and without dementia.

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Trial Profile

Efficacy and Safety of Memantine Hydrochloride, a low affinity antagonist to N-Methyl-D-Aspartate (NMDA) type receptors, in the prevention of cognitive decline and disease progression in older people with Down's syndrome, with and without dementia.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Memantine (Primary)
  • Indications Cognition disorders; Down syndrome
  • Focus Biomarker; Therapeutic Use
  • Acronyms MEADOWS

    • Most Recent Events

    • 14 Jan 2012 Primary endpoint 'Cognitive-function-tests' has not been met.
    • 12 Jan 2012 Results published in the Lancet.
    • 21 Jul 2006 New trial record.

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