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Effect of combination ezetimibe and high-dose simvastatin vs simvastatin alone on the atherosclerotic process in subjects with heterozygous familial hypercholesterolemia (the ENHANCE trial)

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Trial Profile

Effect of combination ezetimibe and high-dose simvastatin vs simvastatin alone on the atherosclerotic process in subjects with heterozygous familial hypercholesterolemia (the ENHANCE trial)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 09 May 2022

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At a glance

  • Drugs Ezetimibe/simvastatin (Primary) ; Simvastatin
  • Indications Atherosclerosis; Hyperlipoproteinaemia type II
  • Focus Therapeutic Use
  • Acronyms ENHANCE
  • Sponsors Merck & Co; Merck Sharp & Dohme; Organon

    • Most Recent Events

    • 15 Jan 2008 Primary endpoint not met; results reported by Merck/Schering-Plough.
    • 20 Nov 2007 Data are being analysed; results are expected to be presented at the American College of Cardiology meeting in 2008.
    • 24 Jul 2006 New trial record.

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