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Phase II Trial of Triapine (NSC #663249, 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbone) Plus Fludarabine (NSC #312887, Fludarabine Monophosphate) in Adults With Aggressive Myeloproliferative Disorders (MPDs) Including Chronic Myelomonocytic Leukemia (CMML) and Chronic Myelogenous Leukemia in Accelerated Phase (CML-AP) or Blast Crisis (CML-BC).

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Trial Profile

Phase II Trial of Triapine (NSC #663249, 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbone) Plus Fludarabine (NSC #312887, Fludarabine Monophosphate) in Adults With Aggressive Myeloproliferative Disorders (MPDs) Including Chronic Myelomonocytic Leukemia (CMML) and Chronic Myelogenous Leukemia in Accelerated Phase (CML-AP) or Blast Crisis (CML-BC).

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 03 Nov 2021

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At a glance

  • Drugs Fludarabine (Primary) ; OCX 191 (Primary)
  • Indications Chronic myeloid leukaemia; Chronic myelomonocytic leukaemia
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 19 Jul 2011 Actual end date (Jul 2010) added as reported by ClinicalTrials.gov.
    • 19 Jul 2011 Status changed from recruiting to completed as reported by ClinicalTrials.gov.
    • 24 Mar 2010 Planned number of patients changed from 35 to 42 as reported by ClinicalTrials.gov record.

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