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Prospective, randomized, double-blind, active-controlled, multicenter trial of abciximab and bivalirudin in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary interventions [PCI] (ISAR-REACT-4).

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Trial Profile

Prospective, randomized, double-blind, active-controlled, multicenter trial of abciximab and bivalirudin in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary interventions [PCI] (ISAR-REACT-4).

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 27 Sep 2023

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At a glance

  • Drugs Abciximab (Primary) ; Heparin (Primary) ; Bivalirudin
  • Indications Embolism and thrombosis; Myocardial infarction
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms ISAR-REACT-4

    • Most Recent Events

    • 25 Sep 2023 Results of Individual Patient Data Meta-Analysis , from MATRIX, VALIDATE-SWEDEHEART, ISAR-REACT 4, ACUITY and BRIGHT; comparing the outcomes of bivalirudin and heparin in patients with non-ST-segment-elevation myocardial infarction undergoing PCI, published in the Circulation
    • 29 Aug 2012 1-Year results presented at the ESC Congress 2012: Annual Congress of the European Society of Cardiology.
    • 23 Nov 2011 Primary endpoint composite of death, larger recurrent myocardial infarction, urgent target vessel revascularisation or mmajor bleed event rates has not been met.

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