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A phase 2, randomized, double-blind study exploring the efficacy, safety and tolerability of tenofovir disoproxil fumarate (DF) [Viread] monotherapy versus emtricitabine plus tenofovir DF fixed-dose combination therapy [Truvada] in subjects currently being treated with adefovir dipivoxil [Hepsera] for chronic hepatitis B and having persistent viral replication.

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Trial Profile

A phase 2, randomized, double-blind study exploring the efficacy, safety and tolerability of tenofovir disoproxil fumarate (DF) [Viread] monotherapy versus emtricitabine plus tenofovir DF fixed-dose combination therapy [Truvada] in subjects currently being treated with adefovir dipivoxil [Hepsera] for chronic hepatitis B and having persistent viral replication.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 05 Oct 2021

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At a glance

  • Drugs Emtricitabine/tenofovir disoproxil fumarate (Primary) ; Tenofovir disoproxil fumarate (Primary)
  • Indications Hepatitis B
  • Focus Pharmacodynamics; Therapeutic Use
  • Sponsors Gilead Sciences

    • Most Recent Events

    • 29 Nov 2013 Results published in the Journal of Hepatology.
    • 31 Oct 2011 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 20 Jun 2010 Results have been published in Gastroenterology.

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