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A Randomized, Double-Blind, Double-Dummy, Parallel Group, Factorial Design Trial to Assess the Efficacy and Safety of up to Six Weeks Treatment With 20mg, 40mg, or 80mg QD Doses of Carvedilol Controlled Release Formulation (COREG CR) or 10mg, 20mg, or 40mg QD Doses of Lisinopril (ZESTRIL) or a Combination of One of the Doses of Each Medication.

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Trial Profile

A Randomized, Double-Blind, Double-Dummy, Parallel Group, Factorial Design Trial to Assess the Efficacy and Safety of up to Six Weeks Treatment With 20mg, 40mg, or 80mg QD Doses of Carvedilol Controlled Release Formulation (COREG CR) or 10mg, 20mg, or 40mg QD Doses of Lisinopril (ZESTRIL) or a Combination of One of the Doses of Each Medication.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 18 Sep 2021

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At a glance

  • Drugs Carvedilol; Lisinopril
  • Indications Hypertension
  • Focus Therapeutic Use
  • Acronyms COSMOS
  • Most Recent Events

    • 26 Dec 2016 Biomarkers information updated
    • 10 Nov 2009 Actual patient number (654) added as reported by ClinicalTrials.gov.
    • 27 Oct 2008 Actual end date (Apr 2008) added as reported by ClinicalTrials.gov.
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