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A Prospective Multi-Centre Randomised, Double-Blind, Active Comparator-Controlled, Parallel-Groups Study Comparing the Fully Human Monoclonal Anti-TNFa Antibody Adalimumab Given Every Second Week With Methotrexate Given Weekly and the Combination of Adalimumab and Methotrexate Administered Over 2 Years in Patients With Early Rheumatiod Arthritis (PREMIER)

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Trial Profile

A Prospective Multi-Centre Randomised, Double-Blind, Active Comparator-Controlled, Parallel-Groups Study Comparing the Fully Human Monoclonal Anti-TNFa Antibody Adalimumab Given Every Second Week With Methotrexate Given Weekly and the Combination of Adalimumab and Methotrexate Administered Over 2 Years in Patients With Early Rheumatiod Arthritis (PREMIER)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 10 Nov 2021

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At a glance

  • Drugs Adalimumab (Primary) ; Methotrexate
  • Indications Rheumatoid arthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms PREMIER
  • Sponsors Abbott Laboratories

    • Most Recent Events

    • 03 Aug 2018 Results of a post-hoc analysis of OPTIMA and PREMIER studies assessing predictors of disease activity and structural progression after treatment with adalimumab plus methotrexate, published in the Annals of the Rheumatic Diseases
    • 16 Jun 2018 Results comparing pain and HAQ-DI from RA-BEGIN, PREMIER, ORAL-START, AMBITION and FUNCTION studies were presented at the 19th Annual Congress of the European League Against Rheumatism.
    • 16 Jun 2018 Results of post-hoc analysis of PREMIER and OPTIMA studies, presented at the 19th Annual Congress of the European League Against Rheumatism.

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