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Randomized Study Comparing an Immuno-Chemotherapy With 6 Cycles of the Monoclonal Anti-CD20 Antibody Rituximab in Combination With 6 Cycles of Chemotherapy With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) at 21-Day Intervals or 14-Day Intervals, Both With or Without Consolidating Radiotherapy or Large Tumour Masses (greater than or equal to 7.5 cm) and/or Extranodal Involvement in Patients With Aggressive CD20 B-Cell Lymphoma Aged 18 to 60 Years With Age-Adjusted IPI=1 (All) or IPI=0 With a Large Tumour Mass (greater than or equal to 7.5 cm) [UNFOLDER 21/14 Study]

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Trial Profile

Randomized Study Comparing an Immuno-Chemotherapy With 6 Cycles of the Monoclonal Anti-CD20 Antibody Rituximab in Combination With 6 Cycles of Chemotherapy With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) at 21-Day Intervals or 14-Day Intervals, Both With or Without Consolidating Radiotherapy or Large Tumour Masses (greater than or equal to 7.5 cm) and/or Extranodal Involvement in Patients With Aggressive CD20 B-Cell Lymphoma Aged 18 to 60 Years With Age-Adjusted IPI=1 (All) or IPI=0 With a Large Tumour Mass (greater than or equal to 7.5 cm) [UNFOLDER 21/14 Study]

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 18 Sep 2021

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At a glance

  • Drugs Cyclophosphamide; Doxorubicin; Prednisone; Rituximab; Vincristine
  • Indications B-cell lymphoma; Burkitt's lymphoma; Follicular lymphoma; Mantle-cell lymphoma
  • Focus Therapeutic Use
  • Acronyms UNFOLDER 14; UNFOLDER 21
  • Most Recent Events

    • 10 Mar 2021 Biomarkers information updated
    • 06 Jun 2012 New source identified and integrated (German Clinical Trials Register, DRKS00003739).
    • 18 Nov 2006 New trial record.
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