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A Phase I Dose Escalation Study of SGN-35 in Patients With Relapsed/Refractory CD30-Positive Hematologic Malignancies.

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Trial Profile

A Phase I Dose Escalation Study of SGN-35 in Patients With Relapsed/Refractory CD30-Positive Hematologic Malignancies.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 28 Oct 2020

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At a glance

  • Drugs Brentuximab vedotin (Primary)
  • Indications Anaplastic large cell lymphoma; Haematological malignancies; Hodgkin's disease; T-cell lymphoma
  • Focus Adverse reactions
  • Sponsors Seagen; Seattle Genetics

    • Most Recent Events

    • 28 Jun 2020 An population PK (POPPK) analysis used data from pediatric (NCT01492088) and adult (NCT00430846) studies of brentuximab vedotin to quantify body size effects on ADC exposure; results published in the Journal of Clinical Pharmacology
    • 29 Jan 2018 Results (n=380) of pooled data from six trials assessing population pk and exposure-response relationships for the antibody-drug conjugate brentuximab vedotin in ctcl patients, were published in the Clinical Pharmacology and Therapeutics.
    • 12 Jun 2011 Retrospective analysis of two phase I trials, including this trial, presented at the16th Congress of the European Haematology Association (EHA-2011).

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