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A prospective, open, randomized, multicenter study comparing the effects of everolimus versus mycophenolate sodium as compared to ciclosporin as maintenance therapy in renal allograft recipients, on chronic allograft damage and cardiovascular parameters.

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Trial Profile

A prospective, open, randomized, multicenter study comparing the effects of everolimus versus mycophenolate sodium as compared to ciclosporin as maintenance therapy in renal allograft recipients, on chronic allograft damage and cardiovascular parameters.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 21 Feb 2019

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At a glance

  • Drugs Ciclosporin (Primary) ; Everolimus (Primary) ; Mycophenolate sodium (Primary) ; Prednisolone
  • Indications Renal transplant rejection
  • Focus Adverse reactions
  • Acronyms MECANO

    • Most Recent Events

    • 17 Sep 2016 Results published in the American Journal of Transplantation
    • 17 Sep 2016 Primary endpoint has been met. (Degree of inflammation and fibrosis and degree of arteriolar hyalinosis in renal biopsies taken at 6 and 24 months after implantation for prednisolone/Everolimus (P/EVL) arm), according to Results published in the American Journal of Transplantation.
    • 17 Sep 2016 Results published in the American Journal of Transplantation

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