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The EMBRACE Trial: Eisai Metastatic BReast cancer study Assessing physician's Choice versus E7389. A phase III open label, randomized, parallel, two-arm, multi-center study of E7389 [eribulin] versus 'treatment of physician's choice' in patients with locally recurrent, metastatic breast cancer, previously treated with at least two and a maximum of five prior chemotherapy regimens, including an anthracycline and a taxane

Trial Profile

The EMBRACE Trial: Eisai Metastatic BReast cancer study Assessing physician's Choice versus E7389. A phase III open label, randomized, parallel, two-arm, multi-center study of E7389 [eribulin] versus 'treatment of physician's choice' in patients with locally recurrent, metastatic breast cancer, previously treated with at least two and a maximum of five prior chemotherapy regimens, including an anthracycline and a taxane

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 08 Feb 2023

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At a glance

  • Drugs Eribulin (Primary)
  • Indications Advanced breast cancer; Carcinoma
  • Focus Registrational; Therapeutic Use
  • Acronyms EMBRACE
  • Sponsors Eisai Co Ltd
  • Most Recent Events

    • 10 Dec 2022 Results of post-hoc analysis of two studies (Studies 305 and 301) comparing ibulin with otherchemotherapeutic agents (treatment of physicians choice and capecitabine, respectively[control]) in patients with both HER2-low and HER2-0 metastatic breast cancer, presented at the 45th Annual San Antonio Breast Cancer Symposium.
    • 01 Dec 2022 According to an Eisai Inc media release, a post hoc subgroup analysis from the trial will be presented at the 2022 San Antonio Breast Cancer Symposium (SABCS).
    • 13 Sep 2022 Results of post-hoc analysis of three trials (NCT00388726, NCT00337103 and NCT02225470) assessing efficacy of eribulin mesylate in HER2-low metastatic breast cancer, presented at the 47th European Society for Medical Oncology Congress.
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