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A randomized clinical trial in patients with recent-onset arthritis to compare the efficacy of DMARD combination therapy including prednisone with combination therapy including adalimumab, a TNF-blocking agent.

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Trial Profile

A randomized clinical trial in patients with recent-onset arthritis to compare the efficacy of DMARD combination therapy including prednisone with combination therapy including adalimumab, a TNF-blocking agent.

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 24 Jul 2024

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At a glance

  • Drugs Adalimumab (Primary) ; Hydroxychloroquine; Methotrexate; Prednisone; Sulfasalazine
  • Indications Arthritis; Rheumatoid arthritis
  • Focus Therapeutic Use
  • Acronyms IMPROVED

    • Most Recent Events

    • 15 Jun 2024 Results assessing the short-term effect on DAS and HAQ of dose escalation of adalimumab in patients with an insufficient response to normal dosed adalimumab, compared to patients not treated with dose escalation presented at the 25th Annual Congress of the European League Against Rheumatism
    • 17 Jun 2017 Results (n=381) assessing association between baseline autoantibody profile and treatment response, presented at the 18th Annual Congress of the European League Against Rheumatism
    • 30 Oct 2013 Results for patients with early disease activity score remission presented at the 77th American College of Rheumatology and the 48th Annual Meeting of the Association of Rheumatology and Health Professionals.

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