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A Multicenter, Randomized, Double-Period, Double - Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis (OPTIMA)

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Trial Profile

A Multicenter, Randomized, Double-Period, Double - Blind Study to Determine the Optimal Protocol for Treatment Initiation With Methotrexate and Adalimumab Combination Therapy in Patients With Early Rheumatoid Arthritis (OPTIMA)

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 23 Dec 2021

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At a glance

  • Drugs Adalimumab (Primary) ; Methotrexate
  • Indications Rheumatoid arthritis
  • Focus Pharmacogenomic; Therapeutic Use
  • Acronyms OPTIMA
  • Sponsors Abbott Laboratories

    • Most Recent Events

    • 09 Apr 2019 Results assessing pharmacogenetic analysis in adalimumab plus methotrexate-treated rheumatoid arthritis patients published in the Clinical and Experimental Rheumatology
    • 03 Aug 2018 Results of a post-hoc analysis of OPTIMA and PREMIER studies assessing predictors of disease activity and structural progression after treatment with adalimumab plus methotrexate, published in the Annals of the Rheumatic Diseases
    • 16 Jun 2018 Results of post-hoc analysis of PREMIER and OPTIMA studies, presented at the 19th Annual Congress of the European League Against Rheumatism.

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