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A randomized multicenter study with non-inferiority hypothesis, comparing the availability to maintain a complete viral suppression by a monotherapy of darunavir/r [ritonavir] to a NRTI [nucleoside reverse transcriptase inhibitor] containing regimen including darunavir/r, in HIV-1 infected patients with previous prolonged complete viral suppression. ANRS 136 MONOI

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A randomized multicenter study with non-inferiority hypothesis, comparing the availability to maintain a complete viral suppression by a monotherapy of darunavir/r [ritonavir] to a NRTI [nucleoside reverse transcriptase inhibitor] containing regimen including darunavir/r, in HIV-1 infected patients with previous prolonged complete viral suppression. ANRS 136 MONOI

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 25 Jul 2022

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At a glance

  • Drugs Darunavir (Primary) ; Nucleoside reverse transcriptase inhibitors; Ritonavir; Saquinavir
  • Indications HIV-1 infections
  • Focus Pharmacodynamics; Therapeutic Use
  • Acronyms MONOI

    • Most Recent Events

    • 26 Jul 2017 Results (n=637) of pooled analysis of NCT00140751, NCT00421551, NCT00946595 trials analysing distribution of ultrasensitive viral load (USVL) and impact of USVL on virological failure presented at the 9th International AIDS Society Conference on HIV Science
    • 07 Dec 2011 Primary endpoint 'Viral-load' has been met.
    • 08 Apr 2011 Actual end date (1 Feb 2011) added as reported by ClinicalTrials.gov.

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