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A 24-week, double-blind, double-dummy, randomized, parallel-group study to investigate the effects of rosiglitazone (extended release tablets), donepezil, and placebo as monotherapy on cognition and overall clinical response in APOE [apolipoprotein E] e4-stratified subjects with mild to moderate Alzheimer's disease. (REFLECT-1)

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A 24-week, double-blind, double-dummy, randomized, parallel-group study to investigate the effects of rosiglitazone (extended release tablets), donepezil, and placebo as monotherapy on cognition and overall clinical response in APOE [apolipoprotein E] e4-stratified subjects with mild to moderate Alzheimer's disease. (REFLECT-1)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 05 Sep 2023

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At a glance

  • Drugs Rosiglitazone (Primary) ; Donepezil
  • Indications Alzheimer's disease
  • Focus Therapeutic Use
  • Acronyms REFLECT-1
  • Sponsors GlaxoSmithKline; GlaxoSmithKline Research & Development; GSK

    • Most Recent Events

    • 05 Jun 2019 This trial has been completed in United Kingdom, according to European Clinical Trials Database.
    • 20 May 2009 Actual initiation date changed from Jan 2007 to Feb 2007 as reported by ClinicalTrials.gov.
    • 20 May 2009 Status changed from recruiting to completed as reported by United Kingdom Clinical Research Network.

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