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A Two-arm, Randomized, Double-blind, Control Group-compared, Multicenter, Phase IIIb Study With Monthly MRI and Biomarker Assessments to Evaluate the Efficacy, Safety, and Tolerability of Rebif New Formulation (IFN Beta-1a) in Subjects With Relapsing Remitting Multiple Sclerosis

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Trial Profile

A Two-arm, Randomized, Double-blind, Control Group-compared, Multicenter, Phase IIIb Study With Monthly MRI and Biomarker Assessments to Evaluate the Efficacy, Safety, and Tolerability of Rebif New Formulation (IFN Beta-1a) in Subjects With Relapsing Remitting Multiple Sclerosis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 10 Nov 2021

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At a glance

  • Drugs Interferon beta-1a (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Biomarker; Therapeutic Use
  • Acronyms IMPROVE
  • Sponsors EMD Serono; Merck Serono

Most Recent Events

  • 12 Oct 2018 Results of a post-hoc analysis assessing the dynamics of pseudoatrophy in RRMS patients treated with Interferon (IFN) beta-1a or placebo, presented at the 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
  • 12 Oct 2018 Results of a post-hoc analysis assessing spatio-temporal characteristics of active MRI lesions, presented at the 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
  • 25 Sep 2018 Results of pooled data from 17 clinical trials and post-marketing surveillance, were published in the Advances in Therapy.

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