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A phase I, randomized, open label, four arm, two period, two 2x2, crossover, drug interaction study to assess steady-state plasma amprenavir and phenytoin pharmacokinetics following administration of fosamprenavir 700mg BID [twice daily] + ritonavir 100mg BID + phenytoin 300mg QD [once daily], fosamprenavir 700mg BID + ritonavir 100 mg BID, phenytoin 300mg QD in healthy adult subjects

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Trial Profile

A phase I, randomized, open label, four arm, two period, two 2x2, crossover, drug interaction study to assess steady-state plasma amprenavir and phenytoin pharmacokinetics following administration of fosamprenavir 700mg BID [twice daily] + ritonavir 100mg BID + phenytoin 300mg QD [once daily], fosamprenavir 700mg BID + ritonavir 100 mg BID, phenytoin 300mg QD in healthy adult subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 23 Aug 2023

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At a glance

  • Drugs Amprenavir (Primary) ; Fosamprenavir; Phenytoin; Ritonavir
  • Indications Epilepsy; HIV infections; Trigeminal neuralgia
  • Focus Pharmacokinetics
  • Sponsors GlaxoSmithKline

    • Most Recent Events

    • 04 Apr 2007 New trial record.

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