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Randomized Phase III Trial of Paclitaxel +Trastuzumab + Lapatinib Versus Paclitaxel + Trastuzumab as Neoadjuvant Treatment of HER2-Positive Primary Breast Cancer.

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Trial Profile

Randomized Phase III Trial of Paclitaxel +Trastuzumab + Lapatinib Versus Paclitaxel + Trastuzumab as Neoadjuvant Treatment of HER2-Positive Primary Breast Cancer.

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 30 Dec 2024

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At a glance

  • Drugs Lapatinib (Primary) ; Paclitaxel; Trastuzumab
  • Indications Advanced breast cancer; Early breast cancer; HER2 positive breast cancer; Male breast cancer
  • Focus Therapeutic Use
  • Most Recent Events

    • 06 Aug 2024 Planned End Date changed from 10 Jul 2024 to 10 Jul 2025.
    • 07 Jun 2022 Results of a pooled analysis of CALGB 40601, NeoALTTO, and NSABP B-41 studies assessed the the association of intrinsic subtypes and gene expression signatures with pathologic complete response and event-free survival presented at the 58th Annual Meeting of the American Society of Clinical Oncology
    • 01 Oct 2021 Results (n=539) of an analysis assessing predictors of nodal pathologic complete response among patients from two clinical studies: CALGB40601 and CALGB40603 published in the Annals of Surgical Oncology

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