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Phase III, Multicenter, Open-label, Randomized Trial of Tarceva vs Chemotherapy in Patients With Advanced NSCLC With Mutations in the TK Domain of the EGFR

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Trial Profile

Phase III, Multicenter, Open-label, Randomized Trial of Tarceva vs Chemotherapy in Patients With Advanced NSCLC With Mutations in the TK Domain of the EGFR

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 15 Jun 2022

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At a glance

  • Drugs Erlotinib (Primary) ; Carboplatin; Cisplatin; Docetaxel; Gemcitabine
  • Indications Carcinoma; Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms EURTAC
  • Most Recent Events

    • 23 Mar 2018 Results (n=1312) assessing the value of early depth of response in predicting long-term outcome in EGFR-mutant lung cancer using data of patients those with either EGFR mutation exon 19 deletion or exon 21 L858R mutations from five phase III randomized trials EURTAC, IPASS, ENSURE, LUX-Lung 3, and LUX-Lung 6, published in the Journal of Thoracic Oncology.
    • 18 Oct 2017 Results assessing Overall survival Adjusting for Post-Progression Treatment Crossover in three phase III trials (EURTAC, ENSURE and OPTIMAL), presented at the 18th World Conference on Lung Cancer
    • 02 Jun 2015 Results from a meta-analysis of 6 trials showing impact on overall survival in patients with EGFR mutations presented at the 51st Annual Meeting of the American Society of Clinical Oncology.
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