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Phase I study of pharmacologically derived hybrid bolus-infusion schedule of flavopiridol (NSC 649890, IND 46,211) [alvocidib] given in timed sequential combination with cytosine arabinoside (ara-C) [cytarabine] and mitoxantrone for adults with relapsed and refractory acute leukemias.

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Trial Profile

Phase I study of pharmacologically derived hybrid bolus-infusion schedule of flavopiridol (NSC 649890, IND 46,211) [alvocidib] given in timed sequential combination with cytosine arabinoside (ara-C) [cytarabine] and mitoxantrone for adults with relapsed and refractory acute leukemias.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 04 Oct 2013

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At a glance

  • Drugs Alvocidib (Primary) ; Cytarabine; Mitoxantrone
  • Indications Acute myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Therapeutic Use

    • Most Recent Events

    • 19 Jul 2011 Status changed from active, no longer recruiting to discontinued as reported by ClinicalTrials.gov.
    • 19 Jul 2011 Planned end date changed from 1 Nov 2007 to 1 Jan 2011 as reported by ClinicalTrials.gov.
    • 10 Nov 2009 Planned end date (1 Nov 2007) added as reported by ClinicalTrials.gov record.

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