Phase II Study of Hyper-CVAD Plus Nelarabine in Previously Untreated T-ALL and Lymphoblastic Lymphoma
Latest Information Update: 18 Dec 2024
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At a glance
- Drugs Nelarabine (Primary) ; Cyclophosphamide; Cytarabine; Dexamethasone; Dexamethasone; Doxorubicin; Filgrastim; Mercaptopurine; Mesna; Methotrexate; Pegaspargase; Prednisone; Venetoclax; Vincristine
- Indications Precursor cell lymphoblastic leukaemia-lymphoma; T-cell lymphoma
- Focus Therapeutic Use
- 01 Dec 2024 The protocol was modified to incorporate PegAsp during consolidation and then venetoclax; the regimen was further amended to dose venetoclax based on the phenotype and response status to reduce risk of myelosuppression as per results published in the Leukemia
- 01 Dec 2024 Results presenting long-term follow-up from the study including the patients treated with the addition of venetoclax, following the amendment published in the Leukemia
- 27 Aug 2024 Planned End Date changed from 31 Oct 2024 to 31 Oct 2026.