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A randomized, open-label, multi-center study to evaluate the efficacy of nilotinib versus best supportive care with or without a tyrosine kinase inhibitor (investigator's choice) in adult patients with gastrointestinal stromal tumors resistant to both imatinib and sunitinib

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Trial Profile

A randomized, open-label, multi-center study to evaluate the efficacy of nilotinib versus best supportive care with or without a tyrosine kinase inhibitor (investigator's choice) in adult patients with gastrointestinal stromal tumors resistant to both imatinib and sunitinib

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 Jan 2020

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At a glance

  • Drugs Nilotinib (Primary) ; Imatinib; Sunitinib
  • Indications Gastrointestinal stromal tumours
  • Focus Registrational; Therapeutic Use
  • Acronyms ENEST
  • Sponsors Novartis

    • Most Recent Events

    • 23 Jun 2012 Additional location (Belgium) added as reported by European Clinical Trials Database record.
    • 12 Feb 2012 Results published in the Annals of Oncology.
    • 04 Oct 2011 Actual end date of the extension trial (NCT00488150) is June 2011.

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