Efficacy of agomelatine (25 mg/day with potential adjustment to 50 mg) given orally on rest/activity circadian rhythms in outpatients with Major Depressive Disorder. A randomized, double-blind international study with parallel groups versus sertraline (50 mg/day with potential adjustment to 100 mg). Six-week treatment plus optional continuation for 18 weeks.

Trial Profile

Efficacy of agomelatine (25 mg/day with potential adjustment to 50 mg) given orally on rest/activity circadian rhythms in outpatients with Major Depressive Disorder. A randomized, double-blind international study with parallel groups versus sertraline (50 mg/day with potential adjustment to 100 mg). Six-week treatment plus optional continuation for 18 weeks.

Completed
Phase of Trial: Phase III

Latest Information Update: 21 Dec 2017

At a glance

  • Drugs Agomelatine; Sertraline
  • Indications Major depressive disorder
  • Focus Registrational; Therapeutic Use
  • Most Recent Events

    • 01 Feb 2010 Results published in the Journal of Clinical Psychiatry.
    • 01 Feb 2010 Primary endpoint 'Sleep measures' has been met.
    • 01 Aug 2007 New trial record.
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