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Part 1: An open label pilot study to determine interstitial and tissue concentrations of aliskiren and effects on the renin- angiotensin system (RAS) in fat and skeletal muscle of hypertensive patients with abdominal obesity. Part 2: A Randomized, Double Blind, 12-weeks Parallel Group Study to Compare Effects of Aliskiren 300 mg and Amlodipine 5 mg on the RAS and Lipid/Carbohydrate Metabolism in Fat and Skeletal Muscle of Hypertensive Patients With Abdominal Obesity.

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Part 1: An open label pilot study to determine interstitial and tissue concentrations of aliskiren and effects on the renin- angiotensin system (RAS) in fat and skeletal muscle of hypertensive patients with abdominal obesity. Part 2: A Randomized, Double Blind, 12-weeks Parallel Group Study to Compare Effects of Aliskiren 300 mg and Amlodipine 5 mg on the RAS and Lipid/Carbohydrate Metabolism in Fat and Skeletal Muscle of Hypertensive Patients With Abdominal Obesity.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 10 Nov 2021

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At a glance

  • Drugs Aliskiren (Primary) ; Amlodipine
  • Indications Hypertension; Obesity
  • Focus Biomarker; Pharmacodynamics; Pharmacokinetics
  • Sponsors Novartis

    • Most Recent Events

    • 09 Jul 2012 Status changed from completed to discontinued as reported by ClinicalTrials.gov.
    • 03 May 2012 Actual patient number added 26 according to ClinicalTrials.gov.
    • 03 May 2012 Actual end date (March 2012) added as reported by ClinicalTrials.gov.

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