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A Randomized Phase III Trial Comparing a Neoadjuvant Regimen of FEC-75 Followed by Paclitaxel Plus Trastuzumab With a Neoadjuvant Regimen of Paclitaxel Plus Trastuzumab Followed by FEC-75 Plus Trastuzumab in Patients With HER-2 Positive Operable Breast Cancer

Trial Profile

A Randomized Phase III Trial Comparing a Neoadjuvant Regimen of FEC-75 Followed by Paclitaxel Plus Trastuzumab With a Neoadjuvant Regimen of Paclitaxel Plus Trastuzumab Followed by FEC-75 Plus Trastuzumab in Patients With HER-2 Positive Operable Breast Cancer

Completed
Phase of Trial: Phase III

Latest Information Update: 13 Nov 2018

At a glance

  • Drugs Trastuzumab (Primary) ; Cyclophosphamide; Epirubicin; Fluorouracil; Paclitaxel
  • Indications Early breast cancer
  • Focus Biomarker; Therapeutic Use
  • Acronyms Alliance
  • Most Recent Events

    • 31 Aug 2018 Biomarkers information updated
    • 01 May 2017 Results (n=48) assessing genomic characterization of HER positive breast cancer patients and its predictive role for treatment efficacy with chemotherapy and trastuzumab using patient data from NCT00513292 and NCT00353483 trials, published in the Annals of Oncology
    • 12 Nov 2013 Primary endpoint 'Complete-pathological-response-rate' has not been met.
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