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A Phase 3 Randomized, Rater-Blinded Study Comparing Two Annual Cycles of Intravenous Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif) in Treatment-Naive Patients With Relapsing-Remitting Multiple Sclerosis

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Trial Profile

A Phase 3 Randomized, Rater-Blinded Study Comparing Two Annual Cycles of Intravenous Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif) in Treatment-Naive Patients With Relapsing-Remitting Multiple Sclerosis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 26 Apr 2022

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At a glance

  • Drugs Alemtuzumab (Primary) ; Interferon beta-1a
  • Indications Multiple sclerosis
  • Focus Registrational; Therapeutic Use
  • Acronyms CARE-MS-I
  • Sponsors Genzyme Corporation

    • Most Recent Events

    • 01 Apr 2022 Results assessing serum neurofilament light chain (sNfL) in CARE-MS I patients and highly active disease (HAD) subgroup, over 7 and 2 years for alemtuzumab and subcutaneous interferon beta-1a , published in the Multiple Sclerosis Journal.
    • 22 Apr 2021 Results of pooled data of CARE-MS studies (NCT00530348; NCT00548405; NCT00930553) presented at the 73rd Annual Meeting of the American Academy of Neurology.
    • 13 Sep 2020 Results (n=1216) of analysis assessing autoimmune adverse events from five clinical studies: NCT00050778, NCT00530348, NCT00548405, NCT00930553, NCT02255656 presented at the 8th Triennial joint meeting of Americas Committee for Treatment and Research in Multiple Sclerosis and the European Committee for Treatment and Research in Multiple Sclerosis
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