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An open-label, randomized, 48-week study to assess the safety, tolerability and activity of raltegravir when replacing the ritonavir-boosted PI [protease-inhibitor] component of HAART [highly active antiretroviral therapy] in HIV-infected individuals with viral load suppression on a ritonavir-boosted PI containing regimen

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Trial Profile

An open-label, randomized, 48-week study to assess the safety, tolerability and activity of raltegravir when replacing the ritonavir-boosted PI [protease-inhibitor] component of HAART [highly active antiretroviral therapy] in HIV-infected individuals with viral load suppression on a ritonavir-boosted PI containing regimen

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 06 Nov 2015

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At a glance

  • Drugs Raltegravir (Primary) ; Antiretrovirals; Atazanavir; Darunavir; Fosamprenavir; HIV protease inhibitors; Indinavir; Lopinavir; Ritonavir; Saquinavir; Tipranavir
  • Indications HIV-1 infections
  • Focus Biomarker; Therapeutic Use
  • Acronyms SPIRAL

    • Most Recent Events

    • 08 Mar 2012 Biomarker and lipid profile results presented at the 19th Conference on Retroviruses and Opportunistic Infections.
    • 22 Nov 2011 Results of the 86 patients included in the SPIRAL-LIP substudy have been reported in AIDS.
    • 18 Jul 2010 Results were presented at the 18th International AIDS Conference

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