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Phase II multicenter study of the impact of the therapeutic sequence of radiochemotherapy (50 Gy + capecitabine + oxaliplatin + cetuximab) followed by total mesorectal excision surgery then post-surgery chemotherapy (FOLFOX4 [fluorouracil + folinic acid + oxaliplatin] + cetuximab) in synchronous locally advanced or metastatic cancers of the rectum with metastases resectable from the start (T3-4 Nx or T2 N+ M1).

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Trial Profile

Phase II multicenter study of the impact of the therapeutic sequence of radiochemotherapy (50 Gy + capecitabine + oxaliplatin + cetuximab) followed by total mesorectal excision surgery then post-surgery chemotherapy (FOLFOX4 [fluorouracil + folinic acid + oxaliplatin] + cetuximab) in synchronous locally advanced or metastatic cancers of the rectum with metastases resectable from the start (T3-4 Nx or T2 N+ M1).

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Sep 2021

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At a glance

  • Drugs Capecitabine; Cetuximab; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Rectal cancer
  • Focus Biomarker; Therapeutic Use
  • Most Recent Events

    • 11 Feb 2020 Biomarkers information updated
    • 18 Oct 2007 New trial record.

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