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A Randomized, Open Label Study to Compare the Complete Pathological Response Rate Achieved With 4 Combinations of Herceptin, Docetaxel and Pertuzumab in Patients With Locally Advanced, Inflammatory or Early Stage HER2 Positive Breast Cancer

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A Randomized, Open Label Study to Compare the Complete Pathological Response Rate Achieved With 4 Combinations of Herceptin, Docetaxel and Pertuzumab in Patients With Locally Advanced, Inflammatory or Early Stage HER2 Positive Breast Cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 23 Nov 2021

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At a glance

  • Drugs Pertuzumab (Primary) ; Trastuzumab (Primary) ; Docetaxel
  • Indications Advanced breast cancer; Early breast cancer; HER2 positive breast cancer; Inflammatory breast cancer
  • Focus Therapeutic Use
  • Acronyms NEOSPHERE
  • Sponsors Roche

    • Most Recent Events

    • 12 Aug 2021 Results (n=53) assessing protein expression of NRG1 in tumors and pCR rates to trastuzumab-based neoadjuvant setting as well as NRG1 gene expression in the NeoSphere trial and its relationship with pathological response, published in the Clinical Cancer Research.
    • 16 Mar 2021 According to a Roche media release, based on data from (NeoSphere, TRYPHAENA, BERENICE,CLEOPATRA ) trials, the Health Canada has granted market authorization to Perjeta (pertuzumab for injection) as a neoadjuvant treatment of patients with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (either >2 cm in diameter or node positive)
    • 14 Dec 2019 Results of integrated retrospective analysis assessing risk of recurrence and death after neoadjuvant systemic therapy by using data from five studies (HannaH, NeoSphere, TRYPHAENA, BERENICE, KRISTINE) presented at the 42nd Annual San Antonio Breast Cancer Symposium.

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